JMJD2D Positive Control peptide (STJ504332)
SPECIFICATIONS
General Information
| Short Description | JMJD2D Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM4D |
| Gene ID | 55693 |
| Uniprot ID | KDM4D_HUMAN |
Additional Info
| Post Translational Modifications | Ubiquitinated via 'Lys-63'-linked ubiquitin chains. Deubiquitinated by USP14 with the help of TRIM14 leading to stabilization. |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Peptide Name | Lysine-Specific Demethylase 4dJmjc Domain-Containing Histone Demethylation Protein 3dJumonji Domain-Containing Protein 2dHistone H3-Trimethyl-L-Lysine(9 Demethylase 4d |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Lysine-Specific Demethylase 4d proteinJmjc Domain-Containing Histone Demethylation Protein 3d proteinJumonji Domain-Containing Protein 2d proteinHistone H3-Trimethyl-L-Lysine(9 Demethylase 4d proteinKDM4D proteinJHDM3D proteinJMJD2D protein |
Information sourced from Uniprot.org