JAK2 Blocking Peptide peptide (Phospho) (STJ505417)

SKU:
STJ505417-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Phospho-JAK2 Blocking Peptide is synthetically produced from the 980-1030 sequence and is suitable for use in western blot applications.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: JAK2
Gene ID: 3717
Uniprot ID: JAK2_HUMAN
Immunogen Region: 980-1030
Immunogen: Synthetic peptide taken within amino acid region 980-1030 on human JAK2 protein. Phosphorylated 1008 & 1009 tyrosine residues.
Tissue Specificity Ubiquitously expressed throughout most tissues.
Post Translational Modifications Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813. Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity. Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity. Also phosphorylated by TEC. Phosphorylated on tyrosine residues in response to interferon gamma signaling. Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol. Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes.
Function Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO).or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
Peptide Name Tyrosine-Protein Kinase Jak2
Janus Kinase 2
Jak-2
Database Links Reactome: R-HSA-1059683
Reactome: R-HSA-110056
Reactome: R-HSA-112411
Reactome: R-HSA-1170546
Reactome: R-HSA-1433557
Reactome: R-HSA-2586552
Reactome: R-HSA-3214858
Reactome: R-HSA-512988
Reactome: R-HSA-5673000
Reactome: R-HSA-5673001
Reactome: R-HSA-6785807
Reactome: R-HSA-6788467
Reactome: R-HSA-6802946
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-69231
Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-8854691
Reactome: R-HSA-8984722
Reactome: R-HSA-9006335
Reactome: R-HSA-9020591
Reactome: R-HSA-9020933
Reactome: R-HSA-9020956
Reactome: R-HSA-9027276
Reactome: R-HSA-9027277
Reactome: R-HSA-9027283
Reactome: R-HSA-9027284
Reactome: R-HSA-912526
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Reactome: R-HSA-9670439
Reactome: R-HSA-9674555
Reactome: R-HSA-9679191
Reactome: R-HSA-9705462
Reactome: R-HSA-9732724
Reactome: R-HSA-982772
Reactome: R-HSA-983231
Cellular Localisation Endomembrane System
Peripheral Membrane Protein
Cytoplasm
Nucleus
Alternative Peptide Names Tyrosine-Protein Kinase Jak2 protein
Janus Kinase 2 protein
Jak-2 protein
JAK2 protein

Information sourced from Uniprot.org

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