iNOS Blocking Peptide peptide (STJ504264)

SKU:
STJ504264-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: iNOS Blocking Peptide is synthetically produced from the 1064-1114 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NOS2
Gene ID: 4843
Uniprot ID: NOS2_HUMAN
Immunogen Region: 1064-1114
Immunogen: Synthetic peptide taken within amino acid region 1064-1114 on human inducible nitric oxide synthase protein.
Tissue Specificity Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes.
Post Translational Modifications Polyubiquitinated.mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
Function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8.
Peptide Name Nitric Oxide Synthase - Inducible
Hepatocyte Nos
Hep-Nos
Inducible No Synthase
Inducible Nos
Inos
Nos Type Ii
Peptidyl-Cysteine S-Nitrosylase Nos2
Database Links Reactome: R-HSA-1222556
Reactome: R-HSA-392154
Reactome: R-HSA-6785807
Reactome: R-HSA-9033241
Reactome: R-HSA-9636249
Cellular Localisation Cytoplasm
Cytosol
Localizes As Discrete Foci Scattered Throughout The Cytosol And In The Presence Of Spsb1 And Spsb4
Exhibits A More Diffuse Cytosolic Localization
Alternative Peptide Names Nitric Oxide Synthase - Inducible protein
Hepatocyte Nos protein
Hep-Nos protein
Inducible No Synthase protein
Inducible Nos protein
Inos protein
Nos Type Ii protein
Peptidyl-Cysteine S-Nitrosylase Nos2 protein
NOS2 protein
NOS2A protein

Information sourced from Uniprot.org

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