IL23 P19 Blocking Peptide peptide (STJ504255)
SPECIFICATIONS
ImmunogenSynthetic peptide corresponding to C terminal region amino acids 162-179 of Human IL23 P19. Peptide was covalently modified. Sequence: FKILRSLQAFAAVAARV
General Information
| Short Description | IL23 P19 Blocking Peptide is synthetically produced from the 162-179 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | IL23A |
| Gene ID | 51561 |
| Uniprot ID | IL23A_HUMAN |
| Immunogen | Synthetic peptide corresponding to C terminal region amino acids 162-179 of Human IL23 P19. Peptide was covalently modified. Sequence: FKILRSLQAFAAVAARV |
| Immunogen Region | 162-179 |
Additional Info
| Tissue Specificity | Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). |
| Function | Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells. |
| Peptide Name | Interleukin-23 Subunit AlphaIl-23 Subunit AlphaIl-23-AInterleukin-23 Subunit P19Il-23p19 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9020933 |
| Cellular Localisation | SecretedSecreted Upon Association With Il12b |
| Alternative Peptide Names | Interleukin-23 Subunit Alpha proteinIl-23 Subunit Alpha proteinIl-23-A proteinInterleukin-23 Subunit P19 proteinIl-23p19 proteinIL23A proteinSGRF proteinUNQ2498 proteinPRO5798 protein |
Information sourced from Uniprot.org