IL18 Blocking Peptide for STJ506220 peptide (STJ505906)

SKU:
STJ505906-250

£289.50
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: IL18 Blocking Peptide for STJ506220 is synthetically produced from the 37-193 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: IL18
Gene ID: 3606
Uniprot ID: IL18_HUMAN
Immunogen Region: 37-193
Specificity: This blocking peptide is recommended for use in combination with IL18 antibody, STJ506220
Immunogen: Recombinant protein corresponding to amino acids within region 37-193 on human IL18 protein.
Function Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Peptide Name Interleukin-18
Il-18
Iboctadekin
Interferon Gamma-Inducing Factor
Ifn-Gamma-Inducing Factor
Interleukin-1 Gamma
Il-1 Gamma
Database Links Reactome: R-HSA-448706
Reactome: R-HSA-5620971
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-9012546 Q14116-2
Reactome: R-HSA-9660826
Cellular Localisation Cytoplasm
Secreted
The Precursor Is Cytosolic
In Response To Inflammasome-Activating Signals
Cleaved And Secreted
Mature Form Is Secreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore
In Contrast
The Precursor Form Is Not Released
Due To The Presence Of An Acidic Region That Is Proteolytically Removed By Casp1 During Maturation
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
Alternative Peptide Names Interleukin-18 protein
Il-18 protein
Iboctadekin protein
Interferon Gamma-Inducing Factor protein
Ifn-Gamma-Inducing Factor protein
Interleukin-1 Gamma protein
Il-1 Gamma protein
IL18 protein
IGIF protein
IL1F4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance