| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
IFI6 Blocking Peptide for STJ505936 is synthetically produced from the 80-130 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
IFI6 |
| Gene ID: |
2537 |
| Uniprot ID: |
IFI6_HUMAN |
| Immunogen Region: |
80-130 |
| Specificity: |
This blocking peptide is recommended for use in combination with IFI6 antibody, STJ505936 |
| Immunogen: |
Synthetic peptide take within amino acid region 80-130 on human Interferon alpha-inducible protein 6. |
| Function | Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses. Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells. Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Modulates innate immune response mediated by RIGI by preventing its activation. |
| Peptide Name | Interferon Alpha-Inducible Protein 6Interferon-Induced Protein 6-16Ifi-6-16 |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMitochondrion Inner Membrane |
| Alternative Peptide Names | Interferon Alpha-Inducible Protein 6 proteinInterferon-Induced Protein 6-16 proteinIfi-6-16 proteinIFI6 proteinG1P3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
