Human ZBTB17 protein (Recombinant) (N-His) (STJP014616)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ZBTB17-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | ZBTB17 |
| Gene ID | 7709 |
| Uniprot ID | ZBT17_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ala188 |
Additional Info
| Post Translational Modifications | Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner. |
| Function | Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription.this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 17Myc-Interacting Zinc Finger Protein 1Miz-1Zinc Finger Protein 151Zinc Finger Protein 60 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Zinc Finger And Btb Domain-Containing Protein 17 proteinMyc-Interacting Zinc Finger Protein 1 proteinMiz-1 proteinZinc Finger Protein 151 proteinZinc Finger Protein 60 proteinZBTB17 proteinMIZ1 proteinZNF151 proteinZNF60 protein |
Information sourced from Uniprot.org