Human ZBED1 protein (Recombinant) (C-His) (STJP014313)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ZBED1-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | ZBED1 |
| Gene ID | 9189 |
| Uniprot ID | ZBED1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asn3-Glu100 |
Additional Info
| Post Translational Modifications | Autosumoylated with SUMO1, SUMO2, and SUMO3. |
| Function | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCGCTGACTA-3' consensus sequences in gene promoters of ribosomal proteins. (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection. |
| Protein Name | E3 Sumo-Protein Ligase Zbed1Dna Replication-Related Element-Binding FactorPutative Ac-Like Transposable ElementZinc Finger Bed Domain-Containing Protein 1Dref Homolog |
| Database Links | Reactome: R-HSA-4551638 |
| Cellular Localisation | NucleusPml BodyIn Granular Structures(Microbial Infection) Upon Interaction With Human Adenovirus Early E1a ProteinThe Protein Is Redistributed To The Peripheral Areas Of Pml Bodies |
| Alternative Protein Names | E3 Sumo-Protein Ligase Zbed1 proteinDna Replication-Related Element-Binding Factor proteinPutative Ac-Like Transposable Element proteinZinc Finger Bed Domain-Containing Protein 1 proteinDref Homolog proteinZBED1 proteinALTE proteinDREF proteinhDREF proteinKIAA0785 proteinTRAMP protein |
Information sourced from Uniprot.org