Human YKL-40/CHI3L1 (YKL-40/CHI3L1) Antibody Pair (STJAP00840)
SPECIFICATIONS
ClonalityMonoclonal/Monoclonal
HostRabbit/Rabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein
General Information
| Short Description | This YKL-40/CHI3L1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R19-3L-2/R34-3O-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CHI3L1 |
| Gene ID | 1116 |
| Uniprot ID | CH3L1_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. |
| Post Translational Modifications | Glycosylated. |
| Function | Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. |
| Protein Name | Chitinase-3-Like Protein 139 Kda Synovial ProteinCartilage Glycoprotein 39Cgp-39Gp-39Hcgp-39Ykl-40 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceCytoplasmPerinuclear RegionEndoplasmic Reticulum |
| Alternative Antibody Pair Names | Chitinase-3-Like Protein 1 antibody pair39 Kda Synovial Protein antibody pairCartilage Glycoprotein 39 antibody pairCgp-39 antibody pairGp-39 antibody pairHcgp-39 antibody pairYkl-40 antibody pairCHI3L1 antibody pair |
Information sourced from Uniprot.org