Human YKL-40/CHI3L1 (YKL-40/CHI3L1) Antibody Pair (STJAP00840)
General Information
| Short Description | This YKL-40/CHI3L1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R19-3L-2/R34-3O-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CHI3L1 |
| Gene ID | 1116 |
| Uniprot ID | CH3L1_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. |
| Post Translational Modifications | Glycosylated. |
| Function | Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. |
| Protein Name | Chitinase-3-Like Protein 139 Kda Synovial ProteinCartilage Glycoprotein 39Cgp-39Gp-39Hcgp-39Ykl-40 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceCytoplasmPerinuclear RegionEndoplasmic Reticulum |
| Alternative Antibody Pair Names | Chitinase-3-Like Protein 1 antibody pair39 Kda Synovial Protein antibody pairCartilage Glycoprotein 39 antibody pairCgp-39 antibody pairGp-39 antibody pairHcgp-39 antibody pairYkl-40 antibody pairCHI3L1 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human YKL-40/CHI3L1 (YKL-40/CHI3L1) Antibody Pair (STJAP00840)
This antibody pair is designed to detect human YKL-40/CHI3L1 (UniProt P36222) and has confirmed reactivity with human samples only.
This antibody pair has been validated for use in ELISA. It is intended for research use only and is not validated for diagnostic or therapeutic applications.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated at 1 mg/mL, formulated in 0.01M PBS at pH 7.2, and purified by affinity chromatography. The clone IDs are R19-3L-2 (capture) and R34-3O-2 (detection).
Optimal working dilutions for both antibodies must be determined by the end user, as pre-defined dilution ranges are not specified for this product.
Both antibodies were raised against a recombinant protein immunogen. Confirmed reactivity is limited to human YKL-40/CHI3L1, and no cross-reactivity data are provided in the current product specifications.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and keep at -20°C. Repeated freeze/thaw cycles should be avoided to maintain activity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.