Human YES1 protein (Recombinant) (N-His) (STJP008785)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human YES1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | YES1 |
| Gene ID | 7525 |
| Uniprot ID | YES_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr94-Leu543 |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition. Palmitoylation at Cys-3 promotes membrane localization. |
| Function | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity. |
| Protein Name | Tyrosine-Protein Kinase YesProto-Oncogene C-YesP61-Yes |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1433557Reactome: R-HSA-1433559Reactome: R-HSA-2029481Reactome: R-HSA-210990Reactome: R-HSA-2682334Reactome: R-HSA-389356Reactome: R-HSA-389513Reactome: R-HSA-3928662Reactome: R-HSA-3928663Reactome: R-HSA-3928665Reactome: R-HSA-8940973Reactome: R-HSA-912631Reactome: R-HSA-9664323Reactome: R-HSA-9664422Reactome: R-HSA-9670439Reactome: R-HSA-9680350 |
| Cellular Localisation | Cell MembraneCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytosolCell JunctionNewly Synthesized Protein Initially Accumulates In The Golgi Region And Traffics To The Plasma Membrane Through The Exocytic PathwayLocalized To Small Puncta Throughout The Cytoplasm And Cell Membrane When In The Presence Of Snail1 |
| Alternative Protein Names | Tyrosine-Protein Kinase Yes proteinProto-Oncogene C-Yes proteinP61-Yes proteinYES1 proteinYES protein |
Information sourced from Uniprot.org