Human YEATS4 protein (Recombinant) (His-Tag) (STJP017488)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human YEATS4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 50% Glycerol, 2mM DTT, 0.2M NaCl, 0.1mM PMSF, 50mM Imidazole |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | YEATS4 |
| Gene ID | 8089 |
| Uniprot ID | YETS4_HUMAN |
| Accession Number | NP_006521 |
| Immunogen | Human |
| Immunogen Region | 1-227aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. |
| Function | Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ).additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell. |
| Protein Name | Yeats Domain-Containing Protein 4Glioma-Amplified Sequence 41Gas41Numa-Binding Protein 1Nubi-1Nubi1 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-8866907 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Yeats Domain-Containing Protein 4 proteinGlioma-Amplified Sequence 41 proteinGas41 proteinNuma-Binding Protein 1 proteinNubi-1 proteinNubi1 proteinYEATS4 proteinGAS41 protein |
Information sourced from Uniprot.org