Human XRN2 protein (Recombinant) (N-His) (STJP008290)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human XRN2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | XRN2 |
| Gene ID | 22803 |
| Uniprot ID | XRN2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu513-Ser737 |
Additional Info
| Function | Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites. |
| Protein Name | 5'-3' Exoribonuclease 2Dhm1-Like ProteinDhp Protein |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Protein Names | 5'-3' Exoribonuclease 2 proteinDhm1-Like Protein proteinDhp Protein proteinXRN2 protein |
Information sourced from Uniprot.org