Human WWP2 protein (Recombinant) (N-His) (STJP003143)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human WWP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | WWP2 |
| Gene ID | 11060 |
| Uniprot ID | WWP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | His601-Glu870 |
Additional Info
| Post Translational Modifications | Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation.in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation.in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2.the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. |
| Protein Name | Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2Atrophin-1-Interacting Protein 2Aip2Hect-Type E3 Ubiquitin Transferase Wwp2Ww Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-8948751Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9013420Reactome: R-HSA-9013507 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2 proteinAtrophin-1-Interacting Protein 2 proteinAip2 proteinHect-Type E3 Ubiquitin Transferase Wwp2 proteinWw Domain-Containing Protein 2 proteinWWP2 protein |
Information sourced from Uniprot.org