Human WTAP protein (Recombinant) (N-His) (STJP005420)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human WTAP-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | WTAP |
| Gene ID | 9589 |
| Uniprot ID | FL2D_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp150 |
Additional Info
| Function | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. |
| Protein Name | Pre-Mrna-Splicing Regulator WtapFemale-Lethal(2d HomologHfl(2dWt1-Associated ProteinWilms Tumor 1-Associating Protein |
| Database Links | Reactome: R-HSA-72203 |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
| Alternative Protein Names | Pre-Mrna-Splicing Regulator Wtap proteinFemale-Lethal(2d Homolog proteinHfl(2d proteinWt1-Associated Protein proteinWilms Tumor 1-Associating Protein proteinWTAP proteinKIAA0105 protein |
Information sourced from Uniprot.org