Function | Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism. |
Protein Name | Wolframin |
Database Links | Reactome: R-HSA-381038Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleCo-Localizes With Atp6v1a In The Secretory Granules In Neuroblastoma Cell Lines |
Alternative Protein Names | Wolframin proteinWFS1 protein |
Information sourced from Uniprot.org