Human WDR5 protein (Recombinant) (His-Tag) (STJP016772)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human WDR5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 0.1M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WDR5 |
| Gene ID | 11091 |
| Uniprot ID | WDR5_HUMAN |
| Accession Number | NP_438172.1 |
| Immunogen | Human |
| Immunogen Region | 1-334aa |
| Immunogen Sequence |
Additional Info
| Function | Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B. |
| Protein Name | Wd Repeat-Containing Protein 5Bmp2-Induced 3-Kb Gene Protein |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-8951664Reactome: R-HSA-9733709Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Wd Repeat-Containing Protein 5 proteinBmp2-Induced 3-Kb Gene Protein proteinWDR5 proteinBIG3 protein |
Information sourced from Uniprot.org