Human WBP2 protein (Recombinant) (His-Tag) (STJP017813)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human WBP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WBP2 |
| Gene ID | 23558 |
| Uniprot ID | WBP2_HUMAN |
| Accession Number | NP_036610.2 |
| Immunogen | Human |
| Immunogen Region | 1-261aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated in repsonse to EGF as well as estrogen and progesterone hormones. Tyr-192 and Tyr-231 are phosphorylated by YES and SRC inducing nuclear translocation. |
| Function | Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Synergizes with YAP1 to enhance PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR. |
| Protein Name | Ww Domain-Binding Protein 2Wbp-2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus When Phosphorylated |
| Alternative Protein Names | Ww Domain-Binding Protein 2 proteinWbp-2 proteinWBP2 protein |
Information sourced from Uniprot.org