Human WARS protein (Recombinant) (His-Tag) (STJP016767)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human WARS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WARS1 |
| Gene ID | 7453 |
| Uniprot ID | SYWC_HUMAN |
| Accession Number | NP_776049 |
| Immunogen | Human |
| Immunogen Region | 1-471aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Proteolytic cleavage generates 2 forms.T1-TrpRS and T2-TrpRS. |
| Function | Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). Isoform 1: Has no angiostatic activity. T2-TrpRS: Possesses an angiostatic activity but has no aminoacylation activity. Inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Isoform 2: Has an angiostatic activity. |
| Protein Name | Tryptophan--Trna Ligase - CytoplasmicInterferon-Induced Protein 53Ifp53Tryptophanyl-Trna SynthetaseTrprsHwrs Cleaved Into - T1-Trprs - T2-Trprs |
| Database Links | Reactome: R-HSA-379716 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Tryptophan--Trna Ligase - Cytoplasmic proteinInterferon-Induced Protein 53 proteinIfp53 proteinTryptophanyl-Trna Synthetase proteinTrprs proteinHwrs Cleaved Into - T1-Trprs - T2-Trprs proteinWARS1 proteinIFI53 proteinWARS proteinWRS protein |
Information sourced from Uniprot.org