Human vWFCP (Von Willebrand Factor Cleaving Protease) Sandwich ELISA Kit (STJE0007269)
SPECIFICATIONS
General Information
| Short Description | This vWFCP Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 21.5pg/mL |
| Detection Limit | 62.5-4000pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | ADAMTS13 |
| Gene ID | 11093 |
| Uniprot ID | ATS13_HUMAN |
| Sample Type | serum, plasma or other biological fluids. |
Additional Info
| Tissue Specificity | Plasma. Expressed primarily in liver. |
| Post Translational Modifications | Glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS13. May also be C-glycosylated on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and also N-glycosylated. These other glycosylations can also facilitate secretion. The precursor is processed by a furin endopeptidase which cleaves off the pro-domain. |
| Function | Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13Adam-Ts 13Adam-Ts13Adamts-13Von Willebrand Factor-Cleaving ProteaseVwf-CpVwf-Cleaving Protease |
| Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214Reactome: R-HSA-75892Reactome: R-HSA-9845619Reactome: R-HSA-9845621 |
| Cellular Localisation | SecretedSecretion Enhanced By O-Fucosylation Of Tsp Type-1 Repeats |
| Alternative ELISA Names | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 13 ELISA kitAdam-Ts 13 ELISA kitAdam-Ts13 ELISA kitAdamts-13 ELISA kitVon Willebrand Factor-Cleaving Protease ELISA kitVwf-Cp ELISA kitVwf-Cleaving Protease ELISA kitADAMTS13 ELISA kitC9orf8 ELISA kitUNQ6102 ELISA kitPRO20085 ELISA kit |
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Information sourced from Uniprot.org