Human VPS4B protein (Recombinant) (N-His) (STJP008234)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human VPS4B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | VPS4B |
| Gene ID | 9525 |
| Uniprot ID | VPS4B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly138-Gly444 |
Additional Info
| Function | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan. (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 4bCell Migration-Inducing Gene 1 ProteinSuppressor Of K(+ Transport Growth Defect 1Protein Skd1 |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-917729 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinMembrane-Associated In The Prevacuolar Endosomal CompartmentLocalized In Hiv-1 Particles Purified From Acutely Infected Cells |
| Alternative Protein Names | Vacuolar Protein Sorting-Associated Protein 4b proteinCell Migration-Inducing Gene 1 Protein proteinSuppressor Of K(+ Transport Growth Defect 1 proteinProtein Skd1 proteinVPS4B proteinSKD1 proteinVPS42 proteinMIG1 protein |
Information sourced from Uniprot.org