Human VPS25 protein (Recombinant) (His-Tag) (STJP017570)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human VPS25-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol 0.1M Nacl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VPS25 |
| Gene ID | 84313 |
| Uniprot ID | VPS25_HUMAN |
| Accession Number | NP_115729 |
| Immunogen | Human |
| Immunogen Region | 1-176aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung. |
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. |
| Protein Name | Vacuolar Protein-Sorting-Associated Protein 25Hvps25Dermal Papilla-Derived Protein 9Ell-Associated Protein Of 20 KdaEscrt-Ii Complex Subunit Vps25 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosome MembraneNucleusNucleoplasmDistributes Diffusely Throughout The Cytoplasm And NucleoplasmBut Exhibits A Punctate Distribution On Coexpression With Chmp6 |
| Alternative Protein Names | Vacuolar Protein-Sorting-Associated Protein 25 proteinHvps25 proteinDermal Papilla-Derived Protein 9 proteinEll-Associated Protein Of 20 Kda proteinEscrt-Ii Complex Subunit Vps25 proteinVPS25 proteinDERP9 proteinEAP20 protein |
Information sourced from Uniprot.org