Human Vitamin D Binding protein (Vitamin D Binding protein) Antibody Pair (STJAP00927)
General Information
| Short Description | This Vitamin D Binding protein antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R05-1X-3/R09-6R-7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purification |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | GC |
| Gene ID | 2638 |
| Uniprot ID | VTDB_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine. |
| Post Translational Modifications | Allele GC*1S is O-glycosylated at Thr-436. The trisaccharide sugar moiety can be modified by the successive removal of neuraminic acid and galactose leaving an O-mceeN-acetyl-galactosamine. This conversion is thought to produce a macrophage-activating factor (Gc-MAF). Only a minor proportion of plasma GC is O-glycosylated. The potential N-glycosylation site predicted at Asn-288 is thought to be nonglycosylated. |
| Function | Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. |
| Protein Name | Vitamin D-Binding ProteinDbpVdbGc Protein-Derived Macrophage Activating FactorGc-MafGcmafGc-GlobulinGroup-Specific ComponentGcVitamin D-Binding Protein-Macrophage Activating FactorDbp-Maf |
| Database Links | Reactome: R-HSA-196791 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Vitamin D-Binding Protein antibody pairDbp antibody pairVdb antibody pairGc Protein-Derived Macrophage Activating Factor antibody pairGc-Maf antibody pairGcmaf antibody pairGc-Globulin antibody pairGroup-Specific Component antibody pairGc antibody pairVitamin D-Binding Protein-Macrophage Activating Factor antibody pairDbp-Maf antibody pairGC antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human Vitamin D Binding protein (Vitamin D Binding protein) Antibody Pair (STJAP00927)
This antibody pair is designed to detect human Vitamin D Binding Protein, with reactivity confirmed for human samples only. The target protein is referenced by UniProt accession P02774.
Both antibodies are rabbit monoclonal IgGs (clone IDs R05-1X-3 and R09-6R-7), supplied unconjugated and purified by affinity chromatography. Both are formulated in 0.01M PBS at pH 7.2.
This pair has been validated for use in ELISA. No other assay formats are listed for this product.
Working concentrations and dilutions are to be determined by the end user and are not specified in the product data. Titration experiments are recommended to establish optimal conditions for each laboratory setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C, and avoid repeated freeze/thaw cycles to maintain activity.
Both antibodies in this pair were raised against a recombinant protein immunogen corresponding to human Vitamin D Binding Protein. No further detail on the immunogen region is provided in the current product data.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.