Human VEGF-C (Vascular Endothelial Growth Factor C) Antibody Pair (STJAP00491)
SPECIFICATIONS
HostRabbit/Goat
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Human VEGF-C protien.Detection Immunogen: Recombinant Human VEGF-C protien.
General Information
| Short Description | This VEGF-C antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Rabbit/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | VEGFC |
| Gene ID | 7424 |
| Uniprot ID | VEGFC_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human VEGF-C protien.Detection Immunogen: Recombinant Human VEGF-C protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. |
| Function | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. |
| Protein Name | Vascular Endothelial Growth Factor CVegf-CFlt4 LigandFlt4-LVascular Endothelial Growth Factor-Related ProteinVrp |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-194313Reactome: R-HSA-195399 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Vascular Endothelial Growth Factor C antibody pairVegf-C antibody pairFlt4 Ligand antibody pairFlt4-L antibody pairVascular Endothelial Growth Factor-Related Protein antibody pairVrp antibody pairVEGFC antibody pair |
Information sourced from Uniprot.org