| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials. There are two populations of channels.the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway. Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane.the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. |
| Protein Name | Non-Selective Voltage-Gated Ion Channel Vdac2Vdac-2Hvdac2Outer Mitochondrial Membrane Protein Porin 2 |
| Database Links | Reactome: R-HSA-5205685Reactome: R-HSA-5689880Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Outer MembraneMembraneMay Localize To Non-Mitochondrial Membranes |
| Alternative Protein Names | Non-Selective Voltage-Gated Ion Channel Vdac2 proteinVdac-2 proteinHvdac2 proteinOuter Mitochondrial Membrane Protein Porin 2 proteinVDAC2 protein |
Information sourced from Uniprot.org
