Human VAPB protein (Recombinant) (N-His) (STJP007481)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human VAPB-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | VAPB |
| Gene ID | 9217 |
| Uniprot ID | VAPB_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Glu124 |
Additional Info
| Function | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. |
| Protein Name | Vesicle-Associated Membrane Protein-Associated Protein B/CVamp-B/Vamp-CVamp-Associated Protein B/CVap-B/Vap-C |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinPresent In Mitochondria-Associated Membranes That Are Endoplasmic Reticulum Membrane Regions Closely Apposed To The Outer Mitochondrial Membrane |
| Alternative Protein Names | Vesicle-Associated Membrane Protein-Associated Protein B/C proteinVamp-B/Vamp-C proteinVamp-Associated Protein B/C proteinVap-B/Vap-C proteinVAPB proteinUNQ484 proteinPRO983 protein |
Information sourced from Uniprot.org