Human VAPA protein (Recombinant) (N-His) (STJP006117)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human VAPA-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | VAPA |
| Gene ID | 9218 |
| Uniprot ID | VAPA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met8-Met132 |
Additional Info
| Function | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. |
| Protein Name | Vesicle-Associated Membrane Protein-Associated Protein AVamp-AVamp-Associated Protein AVap-A33 Kda Vamp-Associated ProteinVap-33 |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-6798695Reactome: R-HSA-9609523 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCell MembraneCell JunctionTight JunctionNucleus MembranePresent In The Plasma Membrane And In Intracellular VesiclesTogether With Snare ProteinsMay Also Associate With The CytoskeletonColocalizes With Ocln At The Tight Junction In Polarized Epithelial Cells |
| Alternative Protein Names | Vesicle-Associated Membrane Protein-Associated Protein A proteinVamp-A proteinVamp-Associated Protein A proteinVap-A protein33 Kda Vamp-Associated Protein proteinVap-33 proteinVAPA proteinVAP33 protein |
Information sourced from Uniprot.org