| Tissue Specificity | Platelets. |
| Post Translational Modifications | (Microbial infection) Stearoylated By S.flexneri N-epsilon-fatty acyltransferase IcsB, thereby disrupting the host actin cytoskeleton. |
| Function | SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism. |
| Protein Name | Vesicle-Associated Membrane Protein 8Vamp-8EndobrevinEdb |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-199992Reactome: R-HSA-432720Reactome: R-HSA-432722Reactome: R-HSA-6798695Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type Iv Membrane ProteinEarly Endosome MembraneLate Endosome MembraneCell MembraneZymogen Granule MembranePerinuclear Vesicular Structures Of The Early And Late EndosomesCoated PitsAnd Trans-GolgiSub-Tight Junctional Domain In Retinal Pigment Epithelium CellsMidbody Region During CytokinesisLumenal OrientedApical Membranes Of Nephric Tubular CellCycles Through The Apical But Not Through The Basolateral Plasma MembraneApical Region Of Acinar CellsIn Zymogen Granule Membranes |
| Alternative Protein Names | Vesicle-Associated Membrane Protein 8 proteinVamp-8 proteinEndobrevin proteinEdb proteinVAMP8 protein |
Information sourced from Uniprot.org
