Human UBQLN2 protein (Recombinant) (N-GST) (STJP006156)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human UBQLN2-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | UBQLN2 |
| Gene ID | 29978 |
| Uniprot ID | UBQL2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile33-Ala126 |
Additional Info
| Function | Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation.required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs). |
| Protein Name | Ubiquilin-2Chap1Dsk2 HomologProtein Linking Iap With Cytoskeleton 2Plic-2Hplic-2Ubiquitin-Like Product Chap1/Dsk2 |
| Database Links | Reactome: R-HSA-8856825 |
| Cellular Localisation | CytoplasmNucleusMembraneCytoplasmic VesicleAutophagosomeColocalizes With A Subset Of ProteasomesNamely Those That Are Cytoskeleton Associated Or Free In The CytosolAssociated With Fibers In Mitotic Cells |
| Alternative Protein Names | Ubiquilin-2 proteinChap1 proteinDsk2 Homolog proteinProtein Linking Iap With Cytoskeleton 2 proteinPlic-2 proteinHplic-2 proteinUbiquitin-Like Product Chap1/Dsk2 proteinUBQLN2 proteinN4BP4 proteinPLIC2 proteinHRIHFB2157 protein |
Information sourced from Uniprot.org