Human UBLCP1 protein (Recombinant) (His-Tag) (STJP019147)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human UBLCP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UBLCP1 |
| Gene ID | 134510 |
| Uniprot ID | UBCP1_HUMAN |
| Accession Number | NP_659486 |
| Immunogen | Human |
| Immunogen Region | 1-318aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues. |
| Function | Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome. |
| Protein Name | Ubiquitin-Like Domain-Containing Ctd Phosphatase 1Nuclear Proteasome Inhibitor Ublcp1 |
| Database Links | |
| Cellular Localisation | NucleusColocalizes With Nuclear Proteasomes |
| Alternative Protein Names | Ubiquitin-Like Domain-Containing Ctd Phosphatase 1 proteinNuclear Proteasome Inhibitor Ublcp1 proteinUBLCP1 protein |
Information sourced from Uniprot.org