| Function | Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 Variant 1Uev-1Croc-1Traf6-Regulated Ikk Activator 1 Beta Uev1a |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-168927Reactome: R-HSA-202424Reactome: R-HSA-2871837Reactome: R-HSA-445989Reactome: R-HSA-450302Reactome: R-HSA-450321Reactome: R-HSA-5205685Reactome: R-HSA-5607764Reactome: R-HSA-9020702Reactome: R-HSA-937039Reactome: R-HSA-937041Reactome: R-HSA-9646399Reactome: R-HSA-9705671Reactome: R-HSA-975110Reactome: R-HSA-975144Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusExcluded From The Nucleolus |
| Alternative Protein Names | Ubiquitin-Conjugating Enzyme E2 Variant 1 proteinUev-1 proteinCroc-1 proteinTraf6-Regulated Ikk Activator 1 Beta Uev1a proteinUBE2V1 proteinCROC1 proteinUBE2V proteinUEV1 proteinP proteinOKcl.19 protein |
Information sourced from Uniprot.org
