Human UBE2M protein (Recombinant) (Tag free) (STJP014557)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human UBE2M-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 50mM HEPES, 2mM DTT, 150mM NaCl, 10% Glycerol, pH 7.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | UBE2M |
| Gene ID | 9040 |
| Uniprot ID | UBC12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Lys183 |
Additional Info
| Function | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. |
| Protein Name | Nedd8-Conjugating Enzyme Ubc12Nedd8 Carrier ProteinUbiquitin-Conjugating Enzyme E2 M |
| Database Links | Reactome: R-HSA-2173789Reactome: R-HSA-5607761Reactome: R-HSA-5676590Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Protein Names | Nedd8-Conjugating Enzyme Ubc12 proteinNedd8 Carrier Protein proteinUbiquitin-Conjugating Enzyme E2 M proteinUBE2M proteinUBC12 protein |
Information sourced from Uniprot.org