Human TXNIP protein (Recombinant) (N-His) (STJP005989)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TXNIP-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TXNIP |
| Gene ID | 10628 |
| Uniprot ID | TXNIP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile32-Ala367 |
Additional Info
| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| Protein Name | Thioredoxin-Interacting ProteinThioredoxin-Binding Protein 2Vitamin D3 Up-Regulated Protein 1 |
| Database Links | Reactome: R-HSA-844456Reactome: R-HSA-9617629Reactome: R-HSA-9660826Reactome: R-HSA-9707564 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Thioredoxin-Interacting Protein proteinThioredoxin-Binding Protein 2 proteinVitamin D3 Up-Regulated Protein 1 proteinTXNIP proteinVDUP1 protein |
Information sourced from Uniprot.org