Human TWIST2 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP008096)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TWIST2-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TWIST2 |
| Gene ID | 117581 |
| Uniprot ID | TWST2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser60-His160 |
Additional Info
| Function | Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. |
| Protein Name | Twist-Related Protein 2Class A Basic Helix-Loop-Helix Protein 39Bhlha39Dermis-Expressed Protein 1Dermo-1 |
| Database Links | Reactome: R-HSA-8878166 |
| Cellular Localisation | NucleusCytoplasmMainly Nuclear During Embryonic DevelopmentCytoplasmic In Adult Tissues |
| Alternative Protein Names | Twist-Related Protein 2 proteinClass A Basic Helix-Loop-Helix Protein 39 proteinBhlha39 proteinDermis-Expressed Protein 1 proteinDermo-1 proteinTWIST2 proteinBHLHA39 proteinDERMO1 protein |
Information sourced from Uniprot.org