Human TTR (Transthyretin) Antibody Pair (STJAP00258)
SPECIFICATIONS
ClonalityMonoclonal/Monoclonal
HostMouse/Mouse
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Human TTR protein.Detection Immunogen: Recombinant Human TTR protein.
General Information
| Short Description | This TTR antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TTR |
| Gene ID | 7276 |
| Uniprot ID | TTHY_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human TTR protein.Detection Immunogen: Recombinant Human TTR protein. |
Additional Info
| Post Translational Modifications | Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYLD1 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation. |
| Function | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. |
| Protein Name | TransthyretinAttrPrealbuminTbpa |
| Database Links | Reactome: R-HSA-2453902Reactome: R-HSA-3000171Reactome: R-HSA-6798695Reactome: R-HSA-975634Reactome: R-HSA-977225Reactome: R-HSA-9918449 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Antibody Pair Names | Transthyretin antibody pairAttr antibody pairPrealbumin antibody pairTbpa antibody pairTTR antibody pairPALB antibody pair |
Information sourced from Uniprot.org