Human TSC22D3 protein (Recombinant) (N-His) (STJP005894)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TSC22D3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TSC22D3 |
| Gene ID | 1831 |
| Uniprot ID | T22D3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Val134 |
Additional Info
| Function | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities. Isoform 1: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. |
| Protein Name | Tsc22 Domain Family Protein 3Dsip-Immunoreactive PeptideProtein DipHdipDelta Sleep-Inducing Peptide ImmunoreactorGlucocorticoid-Induced Leucine Zipper ProteinGilzTsc-22-Like ProteinTsc-22-Related ProteinTsc-22r |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusLocalization Depends On Differentiation Status Of MyoblastsIn Undifferentiated MyoblastsLocalizes To The CytoplasmBut In Differentiating MyoblastLocalizes To The Nucleus |
| Alternative Protein Names | Tsc22 Domain Family Protein 3 proteinDsip-Immunoreactive Peptide proteinProtein Dip proteinHdip proteinDelta Sleep-Inducing Peptide Immunoreactor proteinGlucocorticoid-Induced Leucine Zipper Protein proteinGilz proteinTsc-22-Like Protein proteinTsc-22-Related Protein proteinTsc-22r proteinTSC22D3 proteinDSIPI proteinGILZ protein |
Information sourced from Uniprot.org