Human TRPV5 protein (Recombinant) (N-His) (STJP006065)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRPV5-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRPV5 |
| Gene ID | 56302 |
| Uniprot ID | TRPV5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Pro327 |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 5Trpv5Calcium Transport Protein 2Cat2Epithelial Calcium Channel 1EcacEcac1Osm-9-Like Trp Channel 3Otrpc3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinColocalized With S100a10 And Anax2 Along The Apical Domain Of Kidney Distal Tubular CellsThe Expression Of The Glycosylated Form In The Cell Membrane Is Increased In The Presence Of Wnk3 |
| Alternative Protein Names | Transient Receptor Potential Cation Channel Subfamily V Member 5 proteinTrpv5 proteinCalcium Transport Protein 2 proteinCat2 proteinEpithelial Calcium Channel 1 proteinEcac proteinEcac1 proteinOsm-9-Like Trp Channel 3 proteinOtrpc3 proteinTRPV5 proteinECAC1 protein |
Information sourced from Uniprot.org