Human TRPM2 protein (Recombinant) (N-His) (STJP015241)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRPM2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | TRPM2 |
| Gene ID | 7226 |
| Uniprot ID | TRPM2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys140-Arg358 |
Additional Info
| Post Translational Modifications | Phosphorylation of TRPM2 at Thr-740 by protein kinase C (PKC) counteracts the effect of cytosolic Ca(2+) and elevates the temperature threshold. |
| Function | Isoform 1: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as a ligand-gated ion channel, gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress. The precise physiological activators are under debate.the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change.the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular Ca(2+) passes through the channel and increases channel activity. Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose. Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels. Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels. Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels. Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels. Confers susceptibility to cell death following oxidative stress. Isoform 2: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose. Isoform 3: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 2Estrogen-Responsive Element-Associated Gene 1 ProteinLong Transient Receptor Potential Channel 2Ltrpc-2Ltrpc2Transient Receptor Potential Channel 7Trpc7Transient Receptor Potential Melastatin 2 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPerikaryonCell ProjectionCytoplasmic VesicleLysosomeDetected At The Cell Membrane And In Intracellular Vesicles In Cortical NeuronsDetected On Neuronal Cell Bodies And NeuritesDetected On The Cell Membrane In Polymorphonuclear NeutrophilsDetected On Cytoplasmic Vesicles And Lysosomes In Immature Bone Marrow Dendritic CellsIsoform 1: Cell MembraneIsoform 2: Cell MembraneIsoform 3: Cell Membrane |
| Alternative Protein Names | Transient Receptor Potential Cation Channel Subfamily M Member 2 proteinEstrogen-Responsive Element-Associated Gene 1 Protein proteinLong Transient Receptor Potential Channel 2 proteinLtrpc-2 proteinLtrpc2 proteinTransient Receptor Potential Channel 7 proteinTrpc7 proteinTransient Receptor Potential Melastatin 2 proteinTRPM2 proteinEREG1 proteinKNP3 proteinLTRPC2 proteinTRPC7 protein |
Information sourced from Uniprot.org