Human TRIP10 protein (Recombinant) (His-Tag) (STJP018577)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human TRIP10-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIP10 |
| Gene ID | 9322 |
| Uniprot ID | CIP4_HUMAN |
| Accession Number | NP_004231 |
| Immunogen | Human |
| Immunogen Region | 260-545aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. |
| Post Translational Modifications | Tyrosine phosphorylated. Also phosphorylated by PKA. |
| Function | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. |
| Protein Name | Cdc42-Interacting Protein 4Protein FelicSalt Tolerant ProteinHstpThyroid Receptor-Interacting Protein 10Tr-Interacting Protein 10Trip-10 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013406 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexLysosomeGolgi ApparatusCell MembraneCell ProjectionPhagocytic CupTranslocates To The Plasma Membrane In Response To Insulin StimulationAnd This May Require Active RhoqLocalizes To Cortical Regions Coincident With F-ActinTo Lysosomes And To Sites Of Phagocytosis In MacrophagesAlso Localizes To The GolgiAnd This Requires Akap9Isoform 5: CytoplasmPerinuclear Region |
| Alternative Protein Names | Cdc42-Interacting Protein 4 proteinProtein Felic proteinSalt Tolerant Protein proteinHstp proteinThyroid Receptor-Interacting Protein 10 proteinTr-Interacting Protein 10 proteinTrip-10 proteinTRIP10 proteinCIP4 proteinSTOT proteinSTP protein |
Information sourced from Uniprot.org