Human TRIM31 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007621)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRIM31-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRIM31 |
| Gene ID | 11074 |
| Uniprot ID | TRI31_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala2-Lys91 |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated (in vitro). |
| Function | E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates. Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation. Regulator of Src-induced anchorage independent cell growth. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim31Tripartite Motif-Containing Protein 31 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmMitochondrionPredominantly Expressed In The Cytoplasm But A Fraction Is Associated With The MitochondriaRecruited T Omitochondria After Viral Infection |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Trim31 proteinTripartite Motif-Containing Protein 31 proteinTRIM31 proteinC6orf13 proteinRNF protein |
Information sourced from Uniprot.org