Human TRIM16 protein (Recombinant) (N-His) (STJP007875)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRIM16-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRIM16 |
| Gene ID | 10626 |
| Uniprot ID | TRI16_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys384-Pro564 |
Additional Info
| Post Translational Modifications | Phosphorylated by ULK1. Auto-ubiquitinates via its B-Boxes. |
| Function | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. |
| Protein Name | Tripartite Motif-Containing Protein 16E3 Ubiquitin-Protein Ligase Trim16Estrogen-Responsive B Box Protein |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Tripartite Motif-Containing Protein 16 proteinE3 Ubiquitin-Protein Ligase Trim16 proteinEstrogen-Responsive B Box Protein proteinTRIM16 proteinEBBP protein |
Information sourced from Uniprot.org