SDS-PAGE gel of recombinant human TRAIL TNFSF10 protein under reducing conditions Coomassie stain

Human TRAIL/TNFSF10 protein (Recombinant) (No-Tag) (STJP019329)

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STJP019329
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Short Description :Recombinant-Human TRAIL/TNFSF10-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications:SDS-PAGE/Bioactivity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 300mM NaCl, 0.1mM DTT, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity:Measured in a cytotoxicity assay using Jurkat human acute T cell leukemia cells. The ED50 range ≤4ng/ml.
Gene Symbol:TNFSF10
Gene ID:8743
Uniprot ID:TNF10_HUMAN
Accession Number:NP_003801
Immunogen:Human
Immunogen Region:114-281aa
Immunogen Sequence:MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG
Tissue Specificity Widespread.most predominant in spleen, lung and prostate.
Post Translational Modifications Tyrosine phosphorylated by PKDCC/VLK.
Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 10
Apo-2 Ligand
Apo-2l
Tnf-Related Apoptosis-Inducing Ligand
Protein Trail
Cd Antigen Cd253
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-69416
Reactome: R-HSA-75158
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Secreted
Exists Both As Membrane-Bound And Soluble Form
Alternative Protein Names Tumor Necrosis Factor Ligand Superfamily Member 10 protein
Apo-2 Ligand protein
Apo-2l protein
Tnf-Related Apoptosis-Inducing Ligand protein
Protein Trail protein
Cd Antigen Cd253 protein
TNFSF10 protein
APO2L protein
TRAIL protein

Information sourced from Uniprot.org

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