Human TRAIL R2/DR5/TNFRSF10B protein (Recombinant) (C-His-Avi) {Biotin} (STJP001593)
SPECIFICATIONS
HostHEK293
ConjugationBiotin
ImmunogenDNA sequence encoding Human TRAIL R2/DR5/TNFRSF10B including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
General Information
| Short Description | Recombinant-Human TRAIL R2/DR5/TNFRSF10B-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Formulation | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Storage Instruction | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
Target Information
| Gene Symbol | TNFRSF10B |
| Gene ID | 8795 |
| Uniprot ID | TR10B_HUMAN |
| Immunogen | DNA sequence encoding Human TRAIL R2/DR5/TNFRSF10B including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Immunogen Region | Ile56-Glu182 |
Additional Info
| Post Translational Modifications | (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5Tnf-Related Apoptosis-Inducing Ligand Receptor 2Trail Receptor 2Trail-R2Cd Antigen Cd262 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10b proteinDeath Receptor 5 proteinTnf-Related Apoptosis-Inducing Ligand Receptor 2 proteinTrail Receptor 2 proteinTrail-R2 proteinCd Antigen Cd262 proteinTNFRSF10B proteinDR5 proteinKILLER proteinTRAILR2 proteinTRICK2 proteinZTNFR9 proteinUNQ160 proteinPRO186 protein |
Information sourced from Uniprot.org