Human TRAF4 protein (Recombinant) (N-His) (STJP005942)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TRAF4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TRAF4 |
| Gene ID | 9618 |
| Uniprot ID | TRAF4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln193-Asp444 |
Additional Info
| Post Translational Modifications | Polyubiquitinated, leading to its proteasomal degradation. Ubiquitinated at Lys-263 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. |
| Function | Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway. |
| Protein Name | Tnf Receptor-Associated Factor 4Cysteine-Rich Domain Associated With Ring And Traf Domains Protein 1Metastatic Lymph Node Gene 62 ProteinMln 62Ring Finger Protein 83 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPerinuclear RegionCell JunctionTight JunctionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoskeleton |
| Alternative Protein Names | Tnf Receptor-Associated Factor 4 proteinCysteine-Rich Domain Associated With Ring And Traf Domains Protein 1 proteinMetastatic Lymph Node Gene 62 Protein proteinMln 62 proteinRing Finger Protein 83 proteinTRAF4 proteinCART1 proteinMLN62 proteinRNF83 protein |
Information sourced from Uniprot.org