Tissue Specificity | Detected in heart, kidney, testis, small intestine and peripheral blood leukocytes, and at very low levels in a variety of tissues. |
Post Translational Modifications | |
Function | Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence. |
Protein Name | Thiamine Pyrophosphokinase 1Htpk1Placental Protein 20Pp20Thiamin Pyrophosphokinase 1 |
Database Links | Reactome: R-HSA-196819 |
Cellular Localisation | |
Alternative ELISA Names | Thiamine Pyrophosphokinase 1 ELISA kitHtpk1 ELISA kitPlacental Protein 20 ELISA kitPp20 ELISA kitThiamin Pyrophosphokinase 1 ELISA kitTPK1 ELISA kit |
output | |
Information sourced from Uniprot.org