Human TP53INP1 protein (Recombinant) (N-His-SUMO) (STJP008979)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TP53INP1-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TP53INP1 |
| Gene ID | 94241 |
| Uniprot ID | T53I1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln86-Ser130 |
Additional Info
| Function | Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. |
| Protein Name | Tumor Protein P53-Inducible Nuclear Protein 1Stress-Induced ProteinP53-Dependent Damage-Inducible Nuclear Protein 1P53dinp1 |
| Database Links | Reactome: R-HSA-6803204Reactome: R-HSA-6804756 |
| Cellular Localisation | CytoplasmCytosolNucleusPml BodyCytoplasmic VesicleAutophagosomeShuttles Between The Nucleus And The CytoplasmDepending On Cellular Stress ConditionsAnd Re-Localizes To Autophagosomes On Autophagy Activation |
| Alternative Protein Names | Tumor Protein P53-Inducible Nuclear Protein 1 proteinStress-Induced Protein proteinP53-Dependent Damage-Inducible Nuclear Protein 1 proteinP53dinp1 proteinTP53INP1 proteinP53DINP1 proteinSIP protein |
Information sourced from Uniprot.org