Human TNFRSF10B/DR5/TRAIL-R2/CD262 protein (Recombinant) (C-His&Avi) {Biotin} (STJP020120)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human TNFRSF10B/DR5/TRAIL-R2/CD262 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ile56-Glu182) of Human TNFRSF10B/DR5/TRAIL-R2/CD262 fused with His tag and Avi tag at the C-
General Information
| Short Description | Recombinant-Human TNFRSF10B/DR5/TRAIL-R2/CD262-C-His&Avi protein was developed in hek293 cells using the region Ile56-Glu182. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | TNFRSF10B |
| Gene ID | 8795 |
| Uniprot ID | TR10B_HUMAN |
| Immunogen | Biotinylated Recombinant Human TNFRSF10B/DR5/TRAIL-R2/CD262 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ile56-Glu182) of Human TNFRSF10B/DR5/TRAIL-R2/CD262 fused with His tag and Avi tag at the C- |
| Immunogen Region | Ile56-Glu182 |
Additional Info
| Tissue Specificity | Widely expressed in adult and fetal tissues.very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361.highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract.not detectable in brain. |
| Post Translational Modifications | (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5Tnf-Related Apoptosis-Inducing Ligand Receptor 2Trail Receptor 2Trail-R2Cd Antigen Cd262 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10b proteinDeath Receptor 5 proteinTnf-Related Apoptosis-Inducing Ligand Receptor 2 proteinTrail Receptor 2 proteinTrail-R2 proteinCd Antigen Cd262 proteinTNFRSF10B proteinDR5 proteinKILLER proteinTRAILR2 proteinTRICK2 proteinZTNFR9 proteinUNQ160 proteinPRO186 protein |
Information sourced from Uniprot.org