Human TLE3 protein (Recombinant) (N-His) (STJP007454)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TLE3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TLE3 |
| Gene ID | 7090 |
| Uniprot ID | TLE3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser449-Tyr772 |
Additional Info
| Post Translational Modifications | Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Ubiquitinated at Lys-720 by UBR5 in response to Wnt signaling, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. |
| Protein Name | Transducin-Like Enhancer Protein 3Enhancer Of Split Groucho-Like Protein 3Esg3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947 Q04726-3Reactome: R-HSA-3769402Reactome: R-HSA-4641265Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Transducin-Like Enhancer Protein 3 proteinEnhancer Of Split Groucho-Like Protein 3 proteinEsg3 proteinTLE3 proteinKIAA1547 protein |
Information sourced from Uniprot.org