Human TK1 protein (Recombinant) (C-His) (STJP013090)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TK1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, 8% Trehalose, 2mM EDTA, 0.05% Tween 80, pH6.35. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/ยตg as determined by LAL test. |
Target Information
| Gene Symbol | TK1 |
| Gene ID | 7083 |
| Uniprot ID | KITH_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asn234 |
Additional Info
| Function | Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT). |
| Protein Name | Thymidine Kinase - Cytosolic |
| Database Links | Reactome: R-HSA-69205Reactome: R-HSA-73614 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Thymidine Kinase - Cytosolic proteinTK1 protein |
Information sourced from Uniprot.org