| Short Description : | Recombinant-Human TIMP-2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 0.5 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TIMP2 |
| Gene ID: | 7077 |
| Uniprot ID: | TIMP2_HUMAN |
| Accession Number: | NP_003246 |
| Immunogen: | Human |
| Immunogen Region: | 27-220aa |
| Immunogen Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMCS CSPVHPQQAF CNADVVIRAK AVSEKEVDSG NDIYGNPIKR IQYEIKQIKM FKGPEKDIEF IYTAPSSAVC GVSLDVGGKK EYLIAGKAEG DGKMHITLCD FIVPWDTLST TQKKSLNHRY QMGCECKITR CPMIPCYISS PDECLWMDWV TEKNINGHQA KFFACIKRSD GSCAWYRGAA PPKQEFLD |
| Post Translational Modifications | The activity of TIMP2 is dependent on the presence of disulfide bonds. |
| Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. |
| Protein Name | Metalloproteinase Inhibitor 2Csc-21kTissue Inhibitor Of Metalloproteinases 2Timp-2 |
| Database Links | Reactome: R-HSA-1592389Reactome: R-HSA-6798695Reactome: R-HSA-9839383 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Metalloproteinase Inhibitor 2 proteinCsc-21k proteinTissue Inhibitor Of Metalloproteinases 2 proteinTimp-2 proteinTIMP2 protein |
Information sourced from Uniprot.org
