Human TIMP-2 protein (Recombinant) (C-His) (STJP001362)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human TIMP-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys27-Pro220) of human TIMP2/CSC-21K (Accession #NP_003246.1.) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human TIMP-2-C-His protein was developed in hek293 cells using the region Cys27-Pro220. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | 1.Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2. The IC50 value is approximately 2.5 nM. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | TIMP2 |
| Gene ID | 7077 |
| Uniprot ID | TIMP2_HUMAN |
| Immunogen | Recombinant Human TIMP-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys27-Pro220) of human TIMP2/CSC-21K (Accession #NP_003246.1.) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Cys27-Pro220 |
| Immunogen Sequence | CSCSPVHPQQAFCNADVVIR AKAVSEKEVDSGNDIYGNPI KRIQYEIKQIKMFKGPEKDI EFIYTAPSSAVCGVSLDVGG KKEYLIAGKAEGDGKMHITL CDFIVPWDTLSTTQKKSLNH RYQMGCECKITRCPMIPCYI SSPDECLWMDWVTEKNINGH QAKFFACIKRSDGSCAWYRG AAPPKQEFLDIEDP |
Additional Info
| Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. |
| Protein Name | Metalloproteinase Inhibitor 2Csc-21kTissue Inhibitor Of Metalloproteinases 2Timp-2 |
| Database Links | Reactome: R-HSA-1592389Reactome: R-HSA-6798695Reactome: R-HSA-9839383 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Metalloproteinase Inhibitor 2 proteinCsc-21k proteinTissue Inhibitor Of Metalloproteinases 2 proteinTimp-2 proteinTIMP2 protein |
Information sourced from Uniprot.org